.Attribute Medication, Published online: 18 September 2024 doi:10.1038/ s41591-024-03300-3Genomic and epidemiologic studies uncovered that a novel reassortant viral family tree of the Oropouche infection, which has been spreading in the western side Amazon region of Brazil for about a many years, is actually associated with the recent human outbreaks between 2022 and also 2024.